Function is not working when disable the path_info

When path info On, I am unable to edit/change anythings.
When path info Off, the following thing is not working:-

  1. CSS is not working on site index page but CSS is working on Journal index page.
  2. Admin menu is not working.
  3. Javascript is also not working.

Kindly help me with this.

Continuing the discussion from Failed to load resource: the server responded with a status of 404 (Not Found):

Describe the issue or problem
Please tell us what happens and what you expected to happen.

Steps I took leading up to the issue
For example:

  1. Go to ‘…’
  2. Click on ‘…’
  3. Scroll down to ‘…’
  4. See error

What application are you using?
For example, OJS 3.3.0-4

Additional information
Please add any screenshots, logs or other information we can use to investigate this problem.