Strange Users in the System

I have notice strange users in my User and Roles. for example this: uyubovox@jhgfd.sadsdskfm.com; iwitowwd@hgfdd.emailddtr.com; ewogciyu@akljs.sdgmaipop.com
I cannot disable or remove them. And my system is now unable to send emails or notifications. What’s going on? Please advise.
sami raza